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Challenges in childhood cancer research
Treatment of cancer is one of the major challenges in contemporary biomedical research. Ever since Farber pioneered chemotherapy for treatment of children's leukemia to the current optimized and carefully tailored protocols for treatment of cancer in children, many further successes have been achieved. However, important challenges are still remaining.
For some childhood cancer entities survival rates are still relatively low such as neuroblastoma. Also, a subset of children with leukemia showing initial good response to treatment relapse after some time and thus require novel treatment strategies to ensure long term cure. Finally, the search for novel effective but less toxic drugs is warranted as current intensive multimodal treatment results in both short and long term side effects including increased risk for secondary malignancies.
Towards novel combination molecular therapies.
More information at Speleman Lab
- ALK signaling
- tumor initiating (epi-) genetic regulatory networks
- combination therapy
- novel zebrafish neuroblastoma models
- the molecular basis of cooperative 17q gain
- Noncoding RNAs in T-cell acute leukemia
- PHF6 in T-cell acute leukemia
Last updated: 24 November 2016 - 11:56
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