Centre de Génétique Médicale de Gand Centre de Génétique Médicale de Gand
Bienvenue au Centre de génétique médicale
Le Centre de génétique médicale Gand a trois objectifs principaux: services médicaux, de la recherche et de l'éducation. Nous offrons notre expertise pour le diagnostic et les soins des patients atteints de maladies héréditaires.
Nous aspirons à une meilleure compréhension de ces maladies héréditaires et à traduire cette connaissance en matière d'éducation dans une variété de disciplines.

Vous êtes patient ?
Vous soignant ?

Contact

Information sur les tests de laboratoire:
+32-9-332 24 77

Information sur les consultations:
+32-9-332 36 03

Agenda

f-TALES workshop 26-27 APRIL Leuven - Genomic Medicine

26 avril 2018 - 12:00am

Genomic Medicine is a rapidly developing science-driven approach to health care. It potentially holds great benefits for patients, clinicians, heal

En savoir plus

Nouvelles

A neuronal enhancer network upstream of MEF2C is compromised in patients with Rett-like characteristics.

30 novembre 2018

Hum Mol Genet. 2018 Nov 15. doi: 10.1093/hmg/ddy393. [Epub ahead of print] A neuronal enhancer network upstream of MEF2C is compromised in patients with Rett-like characteristics. D'haene E, Bar-Yaacov R, Bariah I, Vantomme L, Van Loo S, Cobos FA, Verboom K, Eshel R, Alatawna R, ...

En savoir plus

CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments.

26 novembre 2018

ABSTRACTTargeted genome editing by CRISPR/Cas9 is extremely well fitted to generate gene disruptions, although precise sequence replacement by CRISPR/Cas9-mediated homology-directed repair (HDR) suffers from low efficiency, impeding its use for high-throughput knock-in disease modeling. In this study, we used next-generation sequencing (NGS) analysis to determine the effici...

En savoir plus

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

22 novembre 2018

Abstract Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and identify TBX2 as top candidate gene. We show that TBX2 is a constituent of the recently e...

En savoir plus

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

20 septembre 2018

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylationAbstractThe etiological spectrum of ultra-rare developmental disorders remains to be fully defined. Chromatin regulatory mechanisms maintain cellular identity and function, where misregulation may lead to developmental defects. Here, we report pathogenic variations in...

En savoir plus

Copyright 2019 Centre de Génétique Médicale de Gand, Gent.