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Opgelet

04 July 2017

Wegens officiële feestdag zal onze dienst op 11 juli gesloten zijn. Gelieve hiermee rekening te houden bij het verzenden van stalen.

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Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell-Specific Long Noncoding RNAs.

09 June 2017

AbstractHodgkin lymphoma (HL) is a malignancy of germinal center (GC) B-cell origin. To explore the role of long noncoding RNAs (lncRNAs) in HL, we studied lncRNA expression patterns in normal B-cell subsets, HL cell lines, and tiss

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Brugge loopt voor de tweede keer tegen kanker.

09 June 2017

In het provinciehuis Boeverbos is de aftrap gegeven voor Levensloop Brugge 2017.Die tweede editie vindt op 7 en 8 oktober opnieuw plaats op de terreinen van Sport Vlaanderen in Assebroek. Lees het volledige artikel hier:

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En plots was er 15 miljoen euro

09 June 2017

Geert Mortier (Centrum Medische Genetica, UZ Antwerpen), Eric Legius (Centrum Menselijke Erfelijkheid, UZ Leuven

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New Scientist Wetenschapstalent 2017

29 May 2017

Hetty Helsmoortel is één van de top-25 genomineerden in de New Scientist Wetenschapstalent 2017. Hetty heeft in belangrijke mate bijgedragen tot het kankeronderzoek van het Centrum voor Medische Genetica Gent en is inmiddels uitgegroeid tot een m

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MicroRNA-184 is a downstream effector of albuminuria driving renal fibrosis in rats with diabetic nephropathy.

19 April 2017

Zanchi C, Macconi D, Trionfini P, Tomasoni S, Rottoli D, Locatelli M, Rudnicki M, Vandesompele J, Mestdagh P, Remuzzi G, Benigni A, Zoja C.Diabetologia. 2017 Mar 31. doi: 10.1007/s00125-017-4248-9. [Epub ahead of print]PMID: 28364255 [PubM

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Long non-coding RNAs in cutaneous melanoma: clinical perspectives doi: 10.18632/oncotarget.16478

19 April 2017

Eva Hulstaert1, Lieve Brochez1, Pieter-Jan Volders2,3,4, Jo Vandesompele2,3,4 and Pieter Mestdagh

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Model-Based Classification for Digital PCR: Your Umbrella for Rain

19 April 2017

Bart K. M. Jacobs*† , Els Goetghebeur†, Jo Vandesompele‡¶§, Ariane De Ganck¶, Nele Nijs¶, Anneleen Beckers¶, Nina Papazova∥, Nancy H. Roosens∥, and Lieven Clement*†§† Department of Applied Mathematics, Computer Science and Statistics, Ghent Un

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ArrayCGH voor analyse van multipel myeloom stalen

21 March 2017

Op 1 januari 2017 schakelde het centrum voor medische genetica Gent voor de analyse van de multipel myeloom stalen over van conventionele karyotypering naar moleculaire karyotypering (arrayCGH).Op basis van een interne vergelijking en validati

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Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa.

11 January 2017

Abstract: Defects of the V-type proton (H+) ATPase (V-ATPase) impair acidification and intracellular trafficking of membrane-enclosed compartments, including secretory granules, endosomes, and lysosom

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miSTAR: miRNA target prediction through modeling quantitative and qualitative miRNA binding site information in a stacked model structure

05 January 2017

Abstract In microRNA (miRNA) target prediction, typically two levels of information need to be modeled: the num- ber of potential miRNA binding sites present in a target mRNA and the genomic context of each in- dividual site. Sing

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NIPT - BELANGRIJKE MEDEDELING

24 November 2016

De Niet-invasieve prenatale test (NIPT) prijs daalt van € 390 naar € 290 vanaf 1 december 2016. Deze nieuwe prijs zal gehanteerd worden in alle 8 erkende Belgische genetische centra. Sinds enkele jaren wordt de NIPT aangeboden door de Cent

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The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies.

18 November 2016

Abstract: Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the lan

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Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait.

20 September 2016

Abstract: Stage 4S neuroblastoma (NB) is a special type of NB found in infants with metastases at diagnosis and is associated with an excellent outcome due to its remarkable capacity to undergo spontaneous regression. As

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BATCH-GE: Batch analysis of Next-Generation Sequencing data for genome editing assessment.

15 September 2016

AbstractSci Rep. 2016 Jul 27;6:30330. doi: 10.1038/srep30330. Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a ra

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RT-qPCR gene expression analysis in zebrafish: Preanalytical precautions and use of expressed repetitive elements for normalization.

15 September 2016

Abstract Methods Cell Biol. 2016;135:329-42. doi: 10.1016/bs.mcb.2016.02.002. Epub 2016 Mar 4. Gene expression analysis is increasingly important in many fields of biological research. Understanding patterns of expressed genes

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Loss of Type I Collagen Telopeptide Lysyl Hydroxylation Causes Musculoskeletal Abnormalities in a Zebrafish Model of Bruck Syndrome.

15 September 2016

AbstractJ Bone Miner Res. 2016 Aug 19. doi: 10.1002/jbmr.2977. [Epub ahead of print]Bruck syndrome (BS) is a disorder characterized by joint flexion contractures and skeletal dysplasia that shows strong clinical overlap with the brittle bone

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Buried Treasure

27 July 2016

Noncoding DNA makes up the majority of our genomes, much of it being conserved and transcribed. Though the functions of small regulatory RNA molecules are well known, what about so-called long non-coding RNA? Pioneering scientists are diggin

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Identification of long non-coding RNAs involved in neuronal development and intellectual disability

20 June 2016

Recently, exome sequencing led to the identification of causal mutations in 16–31% of patients with intellectual disability (ID), leaving the underlying cause for many patients unidentified. In this context, the noncoding part of the human genome

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Melanomen zijn verslaafd aan SAMMSON

20 June 2016

Melanomen zijn verslaafd aan SAMMSON

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European Society of Human Genetics Poster Awards

27 May 2016

At the European Human Genetics Conference (May 21-24, Barcelona, Spain), Eva De Vilder and Tim Van Damme have won poster awards for their outstanding presentations entitled: 'Rare modifier variants alter the severity of cardiovascular diseas

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Implementation of non-invasive prenatal testing by semiconductor sequencing in a genetic laboratory.

19 May 2016

OBJECTIVES: To implement non-invasive prenatal testing (NIPT) for fetal aneuploidies with semiconductor sequencing in an academic cytogenomic laboratory and to evaluate the first 15 months experience on clinical samples.

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Nieuwe versie aanvraagformulier voor postnataal genetisch onderzoek en aanvraagformulier genetisch onderzoek maligne cellen

18 April 2016

Er is een nieuwe versie van het aanvraagformulier voor postnataal genetisch onderzoek en het aanvraagformulier voor genetisch onderzoek maligne cellen beschikbaar. De nieuwe versie van het aanvraagformulier voor postnataal genetisch onderzoek omva

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C4CC

01 April 2016

Beste C4CC-sympathisanten,Het is bijna niet te geloven maar ondertussen zijn we bijna 2 jaar verder na de succesvolle C4CC fundraising en team building activiteit. Graag hadden we jullie

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‘Rommel-DNA’ speelt rol bij huidkanker

24 March 2016

Vlaamse onderzoekers ontdekken gen dat cruciaal is voor de meest agressieve vorm van huidkanker.Niet-coderend RNA werd vroeger ook wel eens ‘rommel DNA’ genoemd omdat gedacht werd dat het

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Melanoma addiction to the long non-coding RNA SAMMSON

24 March 2016

Abstract: Focal amplifications of chromosome 3p13–3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon

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Breakthrough in diagnosis of melanoma skin cancer

23 March 2016

Summary: Researchers have revealed a remarkable link between malignant melanoma and a non-coding RNA gene called SAMMSON. The SAMMSON gene is expressed in human malignant melanoma and, strikingly, the growth o

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Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin

02 March 2016

Abstract: Over the last years the zebrafish imposed itself as a powerful model to study skeletal diseases, but a limit to its use is the poor characterization of collagen type I, the most

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Straightforward and sensitive RT-qPCR based gene expression analysis of FFPE samples

25 February 2016

AbstractFragmented RNA from formalin-fixed paraffin-embedded (FFPE) tissue is a known obstacle to gene expression analysis. In this study, the impact of RNA integrity, gene-specific reverse transcription and targeted cD

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DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing.

10 February 2016

Abstract: Comprehensive genome-wide DNA methylation studies in neuroblastoma (NB), a childhood tumor that originates from precursor cells of the sympathetic nervous system, are scarce. Recently, we profiled the DNA methylome

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A Nonsense Mutation in FAM161A Is a Recurrent Founder Allele in Dutch and Belgian Individuals With Autosomal Recessive Retinitis Pigmentosa

03 February 2016

PURPOSE: To identify mutations in FAM161A underlying autosomal recessive retinitis pigmentosa (arRP) in the Dutch and Belgian populations and to investigate whether common FAM161A-associated phenotypic features could be iden

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Expanding the clinical and mutational spectrum of the Ehlers-Danlos syndrome, dermatosparaxis type

21 January 2016

AbstractPURPOSE: The Ehlers-Danlos syndrome (EDS), dermatosparaxis type, is a recessively inherited connective tissue disorder caused by deficient activity of ADAMTS-2, an enzyme that cleaves the aminoterminal prope

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Editors of Blood Select the Top 10 Manuscripts of 2015

21 December 2015

Congratulations to Joni Van der Meulen en co, her UTX paper is in the top 10 of Blood 201.More information

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Princess Lilian Foundation Visiting Professorship 2015-2016 awarded to Prof. Dianna Milewicz

21 October 2015

The Center for Medical Genetics (UGent) proudly announces that the Princess Lilian visiting professorship 2015-2016 has been awarded to Prof. Dianna Milewicz from the University of Texas (Houston, USA).

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Last updated: 2017-07-04
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