Center for Medical Genetics Center for Medical Genetics

Constitutional - DNA

Postnatal samples for DNA-research

Blood

Cheek brush

Instructions for cheek cell sample collection

Fresh human tissue other than blood

Formalin-fixed paraffin-embedded tissue

For DNA tests (f.e. the detection of somatic mutation in tumour tissue) it is crucial that the tissue has been fixed with fresh buffered formalin (10% formalin of neutral pH; formalin of too low pH can cause shearing of the DNA strands) and that a fixation duration of 6 to 72 hours is respected. The time between the ressection of the tissue and the fixation must be as short as possible. Reference: Asco guidelines: Wolff et al. J. Clin. Oncol. 2013, 31: 3997-4013.

DNA

Preferably, we get an EDTA blood sample. If you have the patient’s DNA, the following conditions are appropriate for almost any molecular-genetic test:

Fresh blood (indicated as ‘f-E’ on the application form)

BIOCHEMICAL TESTS AND NULL-ALLELE TESTING

Fibroblasts

Skin biopsy



Last updated: 20 March 2017 - 16:37
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